Abstract | BACKGROUND: METHODS: This was a multicenter, randomized, double-blind, vehicle-controlled study in adults with mild-moderate atopic dermatitis. Patients were given MAS063DP or vehicle (2:1) three times per day to areas affected by atopic dermatitis for up to 50 days. A patient global assessment change from baseline was determined at days 8, 22, 36, and 50. Patient total body pruritus (visual analog scale) and patient opinion on treatment acceptability were also assessed. RESULTS: A total of 218 patients (active: n = 145, vehicle: n = 73) were enrolled. At Day 22, 77% of patients on MAS063DP had a patient global assessment of good improvement or better versus 21% on vehicle (p<0.0001, chi-squared test). Similarly, more patients had improvement in itch over their total body on MAS063DP than on vehicle (p<0.0001). CONCLUSION:
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Authors | William Abramovits, Adelaide A Hebert, Mark Boguniewicz, Steven E Kempers, Eduardo Tschen, Michael T Jarratt, Anne W Lucky, Raymond L Cornelison, Leonard J Swinyer, Terry M Jones |
Journal | The Journal of dermatological treatment
(J Dermatolog Treat)
Vol. 19
Issue 6
Pg. 327-32
( 2008)
ISSN: 1471-1753 [Electronic] England |
PMID | 18728923
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Dermatologic Agents
- Dietary Fats
- MAS063DP
- Ointments
- Plant Extracts
- Glycyrrhetinic Acid
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Topics |
- Administration, Cutaneous
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Dermatitis, Atopic
(drug therapy, pathology)
- Dermatologic Agents
(administration & dosage)
- Dietary Fats
(administration & dosage)
- Double-Blind Method
- Female
- Glycyrrhetinic Acid
(administration & dosage)
- Humans
- Male
- Middle Aged
- Ointments
- Plant Extracts
(administration & dosage)
- Severity of Illness Index
- Texas
- Treatment Outcome
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