Follow-up study of cancer incidence after chlorophenol exposure in a community in southern Finland.
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| Abstract | OBJECTIVES: In the 1970s and 1980s, people in a village in southern Finland had been exposed to high concentrations of chlorophenols in the drinking water and in fish from a nearby lake. An ecological analysis and a case-control study conducted around 1990 indicated significant excess in the incidence of non-Hodgkin's lymphoma and soft-tissue cancer in the municipality and a relationship between the chlorophenol exposure and the incidence of these cancers. The present article reports a follow-up of cancer risk in the same study area during a 20-year period after the closing of the old water intake plant, which was contaminated by chlorophenols. METHODS: The observed and expected numbers of cancer were obtained for three periods, 1953-1971 (before exposure), 1972-1986 (during exposure) and 1987-2006 (after exposure), for all cancers combined and separately for cancers potentially related to chlorophenols. RESULTS: The present study demonstrates that all of the cancer risks returned to the average population level during the 20-year period after the old water intake plant was closed and chlorophenol exposure stopped. CONCLUSIONS: The rapid changes in cancer risk after changes in chlorophenol exposure suggest that chlorophenols may have a promotion effect in the carcinogenic process.
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| Authors | Pentti Lampi, Jouko Tuomisto, Timo Hakulinen, Eero Pukkala |
| Journal | Scandinavian journal of work, environment & health (Scand J Work Environ Health) Vol. 34 Issue 3 Pg. 230-3 (Jun 2008) ISSN: 0355-3140 [Print] Finland |
| PMID | 18728913 (Publication Type: Journal Article) |
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