Abstract | OBJECTIVES: METHODS: A total of 124 patients with celiac disease, tested for RIA tTGAb at diagnosis, were typed for HLA-DRB1, -DQA1, and -DQB1 genes and divided according to the number of DQB1*02 alleles: group 1, homozygous; group 2, heterozygous; group 3, negative. RESULTS: The mean of tTGAb indexes was significantly higher in group 1 patients than in group 2 (P < 0.02) and group 3 patients (P < 0.01). Patients with at least 1 DQB1*02 allele showed more often a typical CD and diffuse histological lesions than did patients in the other groups. CONCLUSIONS: The study demonstrates that tTGAb titers are HLA-DQB1*02 dose dependent, with significantly higher levels in homozygous individuals. Moreover, individuals with at least 1 HLA-DQB1*02 allele tend to have a more expressed clinical and histological form of celiac disease.
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Authors | Raffaella Nenna, Barbara Mora, Francesca Megiorni, Maria Cristina Mazzilli, Fabio Massimo Magliocca, Claudio Tiberti, Margherita Bonamico |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 47
Issue 3
Pg. 288-92
(Sep 2008)
ISSN: 1536-4801 [Electronic] United States |
PMID | 18728523
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DQB1 antigen
- Transglutaminases
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Topics |
- Adolescent
- Adult
- Alleles
- Autoantibodies
(blood)
- Celiac Disease
(genetics, immunology, pathology)
- Child
- Child, Preschool
- Female
- Genotype
- HLA-DQ Antigens
(genetics)
- HLA-DQ beta-Chains
- Humans
- Infant
- Male
- Radioimmunoassay
- Risk Factors
- Transglutaminases
(immunology)
- Young Adult
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