Abstract | BACKGROUND AND AIM: METHODS: A total of 467 subjects participated in this study. Serum cortisol and DHEAS levels were determined, and a medical questionnaire regarding medical conditions and lifestyle was administered. In addition, clinical examinations including probing depth (PD), bleeding on probing (BOP), and clinical attachment loss (CAL) were conducted. RESULTS: The subjects were divided into tertiles on the basis of periodontitis severity. When the analysis was stratified by smoking status, we found that cortisol levels were significantly higher in those with severe CAL among subjects who had never smoked. Furthermore, multiple regression analysis showed that a higher level of cortisol was significantly associated with greater numbers of sites with severe CAL only in those who had never smoked, while a somewhat weaker association was also observed regarding cortisol/DHEAS ratio. In contrast, the level of DHEAS in serum was not associated with periodontitis. CONCLUSION: There were significant associations between serum cortisol level, including cortisol/DHEAS ratio, and periodontitis severity in elderly subjects who had never smoked.
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Authors | Aiko Ishisaka, Toshihiro Ansai, Inho Soh, Kiyotoshi Inenaga, Shuji Awano, Akihiro Yoshida, Tomoko Hamasaki, Kazuo Sonoki, Yutaka Takata, Tatsuji Nishihara, Tadamichi Takehara |
Journal | Journal of clinical periodontology
(J Clin Periodontol)
Vol. 35
Issue 10
Pg. 853-61
(Oct 2008)
ISSN: 1600-051X [Electronic] United States |
PMID | 18727654
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Dehydroepiandrosterone
- Hydrocortisone
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Cross-Sectional Studies
- Dehydroepiandrosterone
(blood)
- Female
- Humans
- Hydrocortisone
(blood)
- Male
- Middle Aged
- Periodontal Index
- Periodontitis
(blood)
- Severity of Illness Index
- Sex Factors
- Smoking
(blood)
- Statistics, Nonparametric
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