Abstract | INTRODUCTION: MATERIALS AND METHODS: We investigated the EGFR mutations and/or R497K polymorphism statuses in 225 surgically treated NSCLC cases. 192 adenocarcinoma cases were included. The presence or absence of EGFR polymorphism of exon 13 was analyzed by PCR-RFLP method. RESULTS: EGFR mutations at kinase domain were found from 95 of 225 lung cancer patients. In 86.2% of patients, homo- or heterozygous Lys497 allele was present. No correlation existed between R497K EGFR genotype and clinico-pathological features, such as gender, smoking status, and pathological subtypes. CONCLUSIONS: EGFR mutation status was not correlated with R497KEGFR genotype of lung cancers. In node-negative patients, R497KEGFR genotype was not correlated with disease outcome. In node-positive patients, however, R497K EGFR was significantly associated with better overall survival. This association was attributable to neo-adjuvant or adjuvant chemotherapy. In 46 total gefitinib treated NSCLC patients, the prognosis was not different between the EGFR wild type (GG) patients and AG+AA patients. R497KEGFR polymorphism might be associated with favorable prognosis of advanced lung cancers and correlated with chemosensitivity.
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Authors | Hidefumi Sasaki, Katsuhiro Okuda, Shigeki Shimizu, Minoru Takada, Masaaki Kawahara, Naoto Kitahara, Meinoshin Okumura, Akihide Matsumura, Keiji Iuchi, Tomoya Kawaguchi, Akihito Kubo, Osamu Kawano, Haruhiro Yukiue, Motoki Yano, Yoshitaka Fujii |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 135
Issue 2
Pg. 313-8
(Feb 2009)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 18726117
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA, Neoplasm
- ErbB Receptors
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Topics |
- Amino Acid Substitution
- Carcinoma, Non-Small-Cell Lung
(genetics, surgery)
- DNA, Neoplasm
(genetics)
- ErbB Receptors
(genetics)
- Exons
(genetics)
- Humans
- Lung Neoplasms
(genetics, surgery)
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Prognosis
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