Abstract | OBJECTIVE: To compare the effect of two dose regimes of IVIg (0.5 g/kg vs. 1g/kg given soon after birth) on duration of phototherapy in Rh-isoimmunized neonates 32 week and above gestation. DESIGN: Randomized controlled trial. SETTING: Tertiary care hospital. SUBJECTS: Rh positive blood group neonates of gestation 32 weeks and above born to Rh negative mothers having positive Direct Coombs test and without any major malformation. INTERVENTION: PRIMARY OUTCOME VARIABLE: RESULTS: The mean duration of phototherapy was 77.3+/-57.2 h in low dose group versus 55.4+/-49 h in high dose group (mean difference=21.9; 95% CI-13.1 to 56.9). There was no difference in need for exchange transfusion (21% in both the groups) and requirement of packed red blood cells transfusion (12 transfusions in both groups). The duration of hospital stay was similar [8.4+/-6.9 and 13.6+/-14.8 days, respectively (mean difference=-5.1; 95% CI-12.8 to 2.5)]. No adverse effects of IVIg administration were noted. CONCLUSION: Two regimens of IVIg (0.5 g/Kg or 1 g/Kg) had comparable effect on duration of phototherapy, duration of hospital stay and exchange transfusion requirement, in Rh isoimmunized neonates of gestation 32 weeks and above.
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Authors | G Girish, D Chawla, R Agarwal, V K Paul, A K Deorari |
Journal | Indian pediatrics
(Indian Pediatr)
Vol. 45
Issue 8
Pg. 653-9
(Aug 2008)
ISSN: 0019-6061 [Print] India |
PMID | 18723908
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulins, Intravenous
- Rh-Hr Blood-Group System
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Topics |
- Erythroblastosis, Fetal
(drug therapy)
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Infant, Newborn
- Rh-Hr Blood-Group System
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