Abstract |
To investigate the antiischemic efficacy and duration of action of the dihydropyridine calcium antagonist felodipine, 15 patients with stable exertional angina were enrolled in a double-blind, crossover study comparing 2 doses (5 and 10 mg) of felodipine extended release (ER) and placebo given once daily for 1 week. Bicycle exercise tests were repeated at the end of each treatment period 4 and 24 hours after dosing. Four hours after dosing with both felodipine doses, only 5 patients discontinued the exercise test because of greater than 2 mm of ST-segment depression, whereas 10 continued until exhaustion (p less than 0.01 vs placebo). Compared with placebo, total exercise time was increased by 19% (p less than 0.001), with no difference between doses. After 24 hours, exercise duration was prolonged up to physical exhaustion in 6 patients taking felodipine 10 mg (p less than 0.05 vs both placebo and felodipine 5 mg); moreover, 11 patients taking 10 mg and 5 taking 5 mg increased time to 1 mm of ST depression greater than or equal to 15% compared with exercise time during the placebo test. Mean time to 1 mm of ST depression at 24 hours was increased by 8% with 5 mg and by 18% with 10 mg (p less than 0.001 vs placebo; p less than 0.01 between doses). Total exercise time at 24 hours was increased with both doses (p less than 0.001), with greater efficacy with the 10-mg dose (p less than 0.05 vs 5 mg).(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | G Santoro, S Savonitto, V Di Bello, D Alberti, C Giusti |
Journal | The American journal of cardiology
(Am J Cardiol)
Vol. 68
Issue 5
Pg. 457-62
(Aug 15 1991)
ISSN: 0002-9149 [Print] United States |
PMID | 1872271
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Delayed-Action Preparations
- Felodipine
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Topics |
- Aged
- Angina Pectoris
(diagnosis, drug therapy, physiopathology)
- Chronic Disease
- Delayed-Action Preparations
- Double-Blind Method
- Drug Administration Schedule
- Electrocardiography
- Exercise Test
- Felodipine
(administration & dosage, adverse effects)
- Female
- Hemodynamics
(drug effects)
- Humans
- Male
- Middle Aged
- Monitoring, Physiologic
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