Expression of integrin-linked kinase and its binding partners in chondrosarcoma: association with prognostic significance.

Abstract	Integrin-linked kinase (ILK) and its binding partners alpha-parvin, beta-parvin, Mig-2 and Migfilin are important components of the cell-matrix adhesions implicated in cell motility, growth, survival and ultimately carcinogenesis. Herein, we investigated immunohistochemically the expression of these molecules in cartilaginous neoplasms and explored their involvement in chondrosarcoma pathobiology and behaviour. Our analyses revealed that ILK, alpha-parvin, beta-parvin and Mig-2 are expressed in the majority of chondrosarcomas but in a small proportion of enchondromas, implying that these proteins might have a role in the development and progression of chondrogenic neoplasms. Moreover, our findings highlight the possibilities that ILK might serve as biological marker that could accurately predict a high-grade tumour and that Mig-2 may function as a promising prognostic indicator of high-risk patients.
Authors	Dionysios J Papachristou, Vassiliki Gkretsi, Uma N M Rao, Georgios I Papachristou, Odysseas A Papaefthymiou, Efthimia K Basdra, Chuanyue Wu, Athanasios G Papavassiliou
Journal	European journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 44 Issue 16 Pg. 2518-25 (Nov 2008) ISSN: 1879-0852 [Electronic] England
PMID	18722108 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
Chemical References	Cell Adhesion Molecules Cytoskeletal Proteins FBLIM1 protein, human FERMT3 protein, human Membrane Proteins Microfilament Proteins Neoplasm Proteins PARVA protein, human PARVB protein, human Actinin integrin-linked kinase Protein Serine-Threonine Kinases
Topics	Actinin (metabolism) Adult Aged Aged, 80 and over Bone Neoplasms (enzymology, mortality) Cell Adhesion Molecules Chondrosarcoma (enzymology, mortality) Cytoskeletal Proteins Female Humans Hyaline Cartilage (metabolism) Male Membrane Proteins (metabolism) Microfilament Proteins Middle Aged Neoplasm Proteins (metabolism) Prognosis Protein Serine-Threonine Kinases (metabolism) Survival Analysis

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