Effect of a synthetic adjuvant for inducing anti-tumour immunity.

Abstract

An acylated derivative of muramyl dipeptide (MDP), 6-O-(2-tetradecyl-hexadecanoyl)-muramyl-dipeptide (B30-MDP) is a strong adjuvant effective in inducing cell-mediated immunity. We used B30-MDP as an adjuvant for induction of anti-tumour immunity. Guinea-pigs which were injected repeatedly with a mixture of X-ray-treated leukaemic cells and B30-MDP dissolved in phosphate buffered saline resisted a challenge of leukaemia cells and showed no sign of leukocytosis. The immunity induced was tumour-specific and retained for more than 100 days. These results suggest that B30-MDP is useful as a simple but potent immunotherapeutic tool.

• Authors: T Kataoka, M Kinomoto, M Takegawa, T Tokunaga
• Journal: Vaccine (Vaccine) Vol. 9 Issue 5 Pg. 300-2 (May 1991) ISSN: 0264-410X [Print] Netherlands
• PMID: 1872013 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Immunologic
• Antigens, Neoplasm
• Vaccines
• Acetylmuramyl-Alanyl-Isoglutamine
• B 30-muramyl dipeptide

Topics

• Acetylmuramyl-Alanyl-Isoglutamine (administration & dosage, analogs & derivatives)
• Adjuvants, Immunologic (administration & dosage)
• Animals
• Antigens, Neoplasm (administration & dosage)
• Female
• Guinea Pigs
• Leukemia, B-Cell (immunology, prevention & control)
• Male
• Neoplasms, Experimental (immunology, prevention & control)
• Vaccines (administration & dosage)