Abstract | BACKGROUND: METHODS: The formalin test was conducted after rats received intraperitoneal saline, Sazetidine-A (0.125, 0.25, 0.5, 1, 2 mg/kg), or subcutaneous epibatidine (2.5-5-10 mug/kg). In other experiments, Sazetidine-A was preceded by naloxone (0.5 mg/kg) or mecamylamine (10 mg). Effects of Sazetidine-A and epibatidine on locomotor were tested in an open field, and seizure activity was measured using the Racine scale. Locus coeruleus neuron extracellular single-unit spontaneous discharge was recorded in anesthetized animals after Sazetidine-A and epibatidine. RESULTS: CONCLUSIONS:
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Authors | Giovanni Cucchiaro, Yingxian Xiao, Alfredo Gonzalez-Sulser, Kenneth J Kellar |
Journal | Anesthesiology
(Anesthesiology)
Vol. 109
Issue 3
Pg. 512-9
(Sep 2008)
ISSN: 1528-1175 [Electronic] United States |
PMID | 18719450
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Azetidines
- Bridged Bicyclo Compounds, Heterocyclic
- Cholinergic Agents
- Narcotic Antagonists
- Nicotinic Agonists
- Nicotinic Antagonists
- Pyridines
- Receptors, Nicotinic
- sazetidine-A
- Naloxone
- Sodium Chloride
- Mecamylamine
- epibatidine
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Topics |
- Analgesics
(adverse effects, pharmacology)
- Animals
- Azetidines
(adverse effects, pharmacology)
- Bridged Bicyclo Compounds, Heterocyclic
(administration & dosage)
- Cholinergic Agents
(adverse effects, pharmacology)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Male
- Mecamylamine
(administration & dosage)
- Motor Activity
(drug effects)
- Naloxone
(administration & dosage)
- Narcotic Antagonists
(administration & dosage)
- Nicotinic Agonists
(administration & dosage)
- Nicotinic Antagonists
(administration & dosage)
- Pain
(drug therapy)
- Pain Measurement
(drug effects, methods)
- Pyridines
(administration & dosage, adverse effects, pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptors, Nicotinic
(drug effects, metabolism)
- Sodium Chloride
(administration & dosage)
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