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Treatment of Takayasu's arteritis with tumor necrosis factor antagonists.

Abstract
Four children with Takayasu's arteritis were treated with tumor necrosis factor antagonists because of disease relapse during conventional therapy or as a first-line agent. Two patients went into remission; in the other 2, the response was partial. Anti-tumor necrosis factor agents can have a role in the treatment of Takayasu's arteritis; further controlled studies are required.
AuthorsGiovanni Filocamo, Antonella Buoncompagni, Stefania Viola, Anna Loy, Clara Malattia, Angelo Ravelli, Alberto Martini
JournalThe Journal of pediatrics (J Pediatr) Vol. 153 Issue 3 Pg. 432-4 (Sep 2008) ISSN: 1097-6833 [Electronic] United States
PMID18718263 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Tumor Necrosis Factor-alpha
  • Infliximab
Topics
  • Adolescent
  • Anti-Inflammatory Agents (therapeutic use)
  • Antibodies, Monoclonal (therapeutic use)
  • Child
  • Female
  • Follow-Up Studies
  • Humans
  • Infliximab
  • Magnetic Resonance Angiography
  • Male
  • Retrospective Studies
  • Severity of Illness Index
  • Takayasu Arteritis (diagnosis, drug therapy)
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors)

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