The HLA-DQ beta non-Asp-57 allele: a predictor of future insulin-dependent diabetes mellitus in patients with autoimmune Addison's disease.

Abstract

HLA-DR specificities in 72 Addison's (AD) patients and 808 local controls were compared. We confirmed earlier reports that the HLA-DR3 specificity is significantly increased in AD patients. In our study a relative risk of 3.4 chi 2 = 22.5; pc = 0.01) for the disease was calculated. Analysis of HLA-DQB1 alleles in DR4+ Addison's patients with diabetes mellitus (N = 6) and without IDDM (14 of 18 individuals tested) revealed that the HLA-DQw8 allele (DQB1*0302) was significantly increased in AD patients with IDDM (chi 2 = 13.5; p = 0.001); conversely, a clustering of the HLA-DQw7 allele was detected in DR4+ Addison's patients without IDDM. We thus conclude that particular polymorphic alleles corresponding to non-charged amino acids at position 57 of the HLA-DQ beta-chain [non-Asp-57 alleles] are associated with IDDM also in Addison's patients.

• Authors: B O Boehm, B Manfras, S Seidl, G Holzberger, P Kühnl, C Rosak, K Schöffling, M Trucco
• Journal: Tissue antigens (Tissue Antigens) Vol. 37 Issue 3 Pg. 130-2 (Mar 1991) ISSN: 0001-2815 [Print] England
• PMID: 1871764 (Publication Type: Journal Article)

Chemical References

• HLA-DQ Antigens
• HLA-DQ beta-Chains
• HLA-DQbeta antigen
• HLA-DR3 Antigen

Topics

• Addison Disease (complications, genetics)
• Alleles
• Autoimmune Diseases (genetics)
• Base Sequence
• Diabetes Mellitus, Type 1 (complications, genetics)
• HLA-DQ Antigens (genetics)
• HLA-DQ beta-Chains
• HLA-DR3 Antigen (genetics)
• Haplotypes
• Humans
• Molecular Sequence Data
• Risk Factors