HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Expression of MRP1 gene in acute leukemia.

AbstractCONTEXT AND OBJECTIVE:
Overexpression of the multidrug resistance-associated protein 1 (MRP1) gene has been linked with resistance to chemotherapy in vitro, but little is known about its clinical impact on acute leukemia patients. Our aim was to investigate the possible association between MRP1 gene expression level and clinical outcomes among Iranian leukemia patients.
DESIGN AND SETTING:
This was an analytical cross-sectional study on patients referred to the Hematology, Oncology and Stem Cell Research Center, Sharyatee Public Hospital, whose diagnosis was acute myelogenous leukemia (AML) or acute lymphoblastic leukemia (ALL). All molecular work was performed at NIGEB (public institution).
METHODS:
To correlate with prognostic markers and the clinical outcome of acute leukemia, MRP1 gene expression was assessed in 35 AML cases and 17 ALL cases, using the quantitative real-time polymerase chain reaction and comparing this to the chemotherapy response type.
RESULTS:
Mean expression in AML patients in complete remission (0.032 +/- 0.031) was significantly lower than in relapsed cases (0.422 +/- 0.297). In contrast, no significant difference in MRP1 mRNA level was observed between complete remission and relapsed ALL patients. There was a difference in MRP1 expression between patients with unfavorable and favorable cytogenetic prognosis (0.670 +/- 0.074 and 0.028 +/- 0.013, respectively). MRP1 expression in M5 was significantly higher (p-value = 0.001) than in other subtypes.
CONCLUSIONS:
The findings suggest that high MRP1 expression was associated with poor clinical outcome and was correlated with the M5 subtype and poor cytogenetic subgroups among AML patients but not among ALL patients.
AuthorsFrouzandeh Mahjoubi, Masoud Golalipour, Ardeshir Ghavamzadeh, Kamran Alimoghaddam
JournalSao Paulo medical journal = Revista paulista de medicina (Sao Paulo Med J) Vol. 126 Issue 3 Pg. 172-9 (May 01 2008) ISSN: 1516-3180 [Print] Brazil
PMID18711657 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Multidrug Resistance-Associated Proteins
  • RNA, Messenger
  • multidrug resistance-associated protein 1
Topics
  • Adolescent
  • Adult
  • Antineoplastic Agents (therapeutic use)
  • Case-Control Studies
  • Drug Resistance, Multiple (genetics)
  • Drug Resistance, Neoplasm (genetics)
  • Female
  • Gene Expression Regulation, Leukemic (genetics)
  • Humans
  • Leukemia, Myeloid, Acute (drug therapy, genetics)
  • Male
  • Middle Aged
  • Multidrug Resistance-Associated Proteins (genetics, metabolism)
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics)
  • RNA, Messenger (genetics)
  • Reverse Transcriptase Polymerase Chain Reaction (methods)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: