Abstract | OBJECTIVE: Complement activation and ineffective clearance of complement-bearing immune complexes via erythrocytes contribute to the pathogenesis of systemic lupus erythematosus (SLE). Abnormally high levels of erythrocyte C4d and low levels of complement receptor 1 (CD35) have been reported in SLE and might have diagnostic utility. We investigated whether erythrocyte C4d and complement receptor 1 were specific for SLE and whether there was any association with disease activity. METHODS: RESULTS: Within the SLE population, there was no association with disease activity measured by the physician's global assessment or SELENA SLE Disease Activity Index, nor with past or current lupus nephritis. Assays were not specific for SLE, with higher levels also seen in antiphospholipid syndrome. CONCLUSION: Overlap of erythrocyte C4d and CD35 between SLE and other rheumatic diseases limits their utility as diagnostic tests. However, longitudinal investigation of these assays is warranted, especially given the higher levels in some patients with primary antiphospholipid syndrome.
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Authors | Vandana Singh, James A Mahoney, Michelle Petri |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 35
Issue 10
Pg. 1989-93
(Oct 2008)
ISSN: 0315-162X [Print] Canada |
PMID | 18709693
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- CR1 protein, human
- Peptide Fragments
- Receptors, Complement 3b
- Complement C4b
- complement C4d
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Topics |
- Biomarkers
(blood)
- Case-Control Studies
- Complement C4b
- Erythrocytes
(immunology)
- Female
- Humans
- Lupus Erythematosus, Systemic
(immunology)
- Male
- Middle Aged
- Peptide Fragments
(blood)
- Receptors, Complement 3b
(blood)
- Severity of Illness Index
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