Semi-interpenetrating polymer networks composed of silk fibroin and poly(ethylene glycol) for wound dressing.

• Abstract: Semi-interpenetrating polymer networks (SIPNs) composed of silk fibroin (SF) and poly(ethylene glycol) (PEG) were prepared by photopolymerization of a PEG macromer in the presence of SF to improve the mechanical properties of SF sponge as wound dressing. The morphological structure of the SF/PEG SIPNs was observed to be composed of an interconnected microporous surface and a cross-sectional area. SF/PEG SIPNs showed non-cytotoxicity evaluated by a cell proliferation method using L929 fibroblasts. Wound contraction treated with SF/PEG SIPNs sponges was faster than that of Vaseline gauze as a control. Histological observation confirmed that the deposition of collagen in the dermis was organized by covering the wound area with SF/PEG SIPNs. The above results indicated that SF/PEG SIPNs could be used as wound dressing.
• Authors: Haeyong Kweon, Joo-hong Yeo, Kwang-gill Lee, Hyun Chul Lee, Hee Sam Na, Young Ho Won, Chong Su Cho (Affiliation: Applied Sericulture and Apiculture Division, National Institute of Agricultural Science and Technology, Suwon 441100, Korea.)
• Journal: Biomedical materials (Bristol, England) (Biomed Mater) Vol. 3 Issue 3 Pg. 034115 (Sep 2008) ISSN: 1748-605X [Electronic] England
• PMID: 18708709 (Publication Type: Journal Article)

Chemical References

• Biocompatible Materials
• Polyethylene Glycols
• Polymers
• Silk
• Fibroins

Topics

• Animals
• Bandages
• Biocompatible Materials (chemistry, therapeutic use)
• Cell Line
• Fibroblasts (cytology, drug effects)
• Fibroins (chemistry)
• Male
• Materials Testing
• Mice
• Polyethylene Glycols (chemistry)
• Polymers (chemistry)
• Porosity
• Rats
• Rats, Sprague-Dawley
• Silk (chemistry)
• Wound Healing (physiology)
• Wounds, Penetrating (pathology, therapy)