Ocular neuromyotonia in a 15-year-old girl after radiation therapy.

Abstract

A 15-year-old girl, previously treated with radiation, chemotherapy, and surgery for a posterior fossa medulloblastoma and parasellar metastasis at age 8, presented with a 10-month history of episodic horizontal diplopia. She was diagnosed with ocular neuromyotonia and successfully treated with oral carbamazepine. Given the strong association between peripheral neuromyotonia and the presence of autoimmune antivoltage-gated potassium channels, the patient's blood was tested and found negative for these autoantibodies. This is the first time this has been verified in a person with ocular neuromyotonia.

• Authors: Alexandre de Saint Sardos, Angela Vincent, Maryam Aroichane, Luis H Ospina
• Journal: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus (J AAPOS) Vol. 12 Issue 6 Pg. 616-7 (Dec 2008) ISSN: 1528-3933 [Electronic] United States
• PMID: 18706840 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Potassium Channels, Voltage-Gated
• Carbamazepine

Topics

• Adolescent
• Autoantibodies (blood)
• Carbamazepine (therapeutic use)
• Cerebellar Neoplasms (pathology, radiotherapy)
• Combined Modality Therapy
• Cranial Fossa, Posterior
• Female
• Follow-Up Studies
• Humans
• Isaacs Syndrome (drug therapy, etiology, immunology)
• Medulloblastoma (radiotherapy, secondary)
• Ocular Motility Disorders (drug therapy, etiology, immunology)
• Pituitary Neoplasms (radiotherapy)
• Potassium Channels, Voltage-Gated (immunology)
• Radiation Injuries (complications)
• Sella Turcica