Abstract | BACKGROUND: METHODS: RESULTS: Twenty-four hours after pretreatment, immunoblotting showed HSP72 expression increased in the SNAP group compared with control groups, and this was blocked by CHE. Myocardial infarct size in the SNAP group was smaller than that of the control group ((32.4 +/- 5.8)% vs (51.1 +/- 4.7)%, P < 0.05). Pretreated with CHE abolished the infarct size-limiting effect of SNAP ((46.0 +/- 5.1)%). Pretreatment with Zaprinast neither induced HSP72 expression nor reduced infarct size ((55.4 +/- 5.4)%). CONCLUSION: NO induced HSP72 expression and a delayed protection to the heart via the activities of protein kinase C by a cyclic GMP-independent pathway.
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Authors | Wei-jie Li, Zhi-jing Zhao, Bing Liu, Dian-xin Zhang, Fei Li, Hai-chang Wang, Wen-yi Guo, Guo-liang Jia, Masafumi Kitakaze, Masatsugu Hori |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 121
Issue 12
Pg. 1109-13
(Jun 20 2008)
ISSN: 0366-6999 [Print] China |
PMID | 18706228
(Publication Type: Journal Article)
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Chemical References |
- Benzophenanthridines
- HSP72 Heat-Shock Proteins
- Nitric Oxide Donors
- Phosphodiesterase Inhibitors
- Purinones
- Nitric Oxide
- S-Nitroso-N-Acetylpenicillamine
- chelerythrine
- Protein Kinase C
- zaprinast
- Cyclic GMP
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Topics |
- Animals
- Benzophenanthridines
(pharmacology)
- Cyclic GMP
(metabolism)
- HSP72 Heat-Shock Proteins
(biosynthesis)
- Hemodynamics
- Male
- Myocardial Infarction
(metabolism, physiopathology, prevention & control)
- Myocardial Ischemia
(metabolism, physiopathology, prevention & control)
- Nitric Oxide
(metabolism)
- Nitric Oxide Donors
(pharmacology)
- Phosphodiesterase Inhibitors
(pharmacology)
- Protein Kinase C
(metabolism)
- Purinones
(pharmacology)
- Rabbits
- S-Nitroso-N-Acetylpenicillamine
(pharmacology)
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