HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C).

Abstract
Unlike polyribonucleotides, such as poly(I:C), chlorite-oxidized oxyamylose (COAM) has been poorly characterized as a polyanionic antiviral. COAM possesses a controversial interferon (IFN)-inducing capacity and its mechanism of action has not been elucidated. In this study, COAM was biochemically characterized and fractionated according to molecular mass. In comparison with a strong IFN induction and upregulation of the helicase RIG-I and MDA-5 mRNAs by poly(I:C), COAM did not enhance IFN-alpha or -beta and IFN-inducible RNA helicases in mouse fibroblastoid cells. Instead, COAM inhibited virus entry by blocking the attachment to the cells. These results suggest that COAM can alter the outcome of infection, not by IFN induction and in turn modifying the cellular antiviral state, but through inhibition of virus entry into cells.
AuthorsSandra Li, Erik Martens, Chris Dillen, Philippe E Van den Steen, Ghislain Opdenakker
JournalBiochemical pharmacology (Biochem Pharmacol) Vol. 76 Issue 7 Pg. 831-40 (Oct 01 2008) ISSN: 1873-2968 [Electronic] England
PMID18703022 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiviral Agents
  • Interferon-alpha
  • RNA, Messenger
  • RNA, Viral
  • oxyamylose
  • Interferon-beta
  • Amylose
  • Poly I-C
Topics
  • Amylose (analogs & derivatives, pharmacology)
  • Animals
  • Antiviral Agents (pharmacology)
  • Cell Line
  • Interferon-alpha (genetics)
  • Interferon-beta (genetics)
  • Mengovirus (drug effects, physiology)
  • Mice
  • Poly I-C (pharmacology)
  • RNA, Messenger (metabolism)
  • RNA, Viral (genetics)
  • Virus Internalization (drug effects)
  • Virus Replication (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: