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[Adult T cell lymphoma/leukemia with alopecia, huge tumors of scalp and wide destruction of cerebral bone].

Abstract
We reported rare manifestations of adult T cell lymphoma/leukemia. Patient was 41 year-old woman who has had progressive alopecia from childhood and developed multiple huge tumors (largest 10 x 15 cm) of scalp and wide destruction of cerebral bone at age of 39. A few abnormal lymphocytes (10%) appeared in the peripheral smear. Surface markers of peripheral lymphocytes showed two populations of CD4+/CD8- and CD4+/CD8+. HTLV-1 proviral DNA was demonstrated in the peripheral lymphocytes. Serum anti-ATLA antibodies was positive (X80). Biopsy of tumor revealed diffuse and large cell type of malignant lymphoma. Magnetic resonance imaging of head showed that tumors lysed the bone and invaded into cerebral regions. She was treated with CHOP regimen and irradiation, resulting of decreased tumor size and population of CD4+/CD8+.
AuthorsH Natsuda, Y Muraki, T Kobayashi, H Kozima, A Shibuya, T Nagasawa, T Abe
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 32 Issue 5 Pg. 537-41 (May 1991) ISSN: 0485-1439 [Print] Japan
PMID1870271 (Publication Type: Case Reports, English Abstract, Journal Article)
Topics
  • Adult
  • Alopecia (etiology)
  • Female
  • Humans
  • Leukemia, T-Cell (complications, pathology)
  • Scalp
  • Skin Neoplasms (pathology)
  • Skull Neoplasms (pathology)

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