Abstract | PURPOSE: METHODS: Ninety-five male and female patients (mean age 72.5 years.) were assigned randomly in a double-masked manner to receive 0.3 or 1 mg of pegaptanib sodium every 6 weeks over a 48-week period. Efficacy was assessed by visual acuity change from baseline as the proportion of patients who lost fewer than 15 letters at week 54 using the Early Treatment Diabetic Retinopathy Study chart. RESULTS: The group that received 0.3 mg pegaptanib experienced a mean loss of 3.8 letters; 78.7% (37/47) of patients lost fewer than 15 letters. The 1 mg group had a change of -4.3 letters and the proportion that lost 15 letters was 72.9% (35/48). The proportion of patients whose visual acuity was unchanged or improved was 46.8% (22/47) and 43.8% (21/48) in the 0.3 and 1 mg groups, respectively. The majority of adverse events with possible, probable, or unknown relationship to pegaptanib were related to the intravitreal injection, such as mild conjunctival hemorrhage (0.3 mg: 76.6%, 1 mg: 77.1%) and superficial punctuate keratitis by sterilization (0.3 mg: 29.8%, 1 mg: 39.6%) at the injection site. Compliance with the study treatment of 9 intravitre al injections was as high as 87.2% and 85.4% for patients receiving 0.3 and 1 mg, respectively. CONCLUSION:
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Authors | Yasuo Tano, Pegaptanib Sodium Multi-center Study Group |
Journal | Nippon Ganka Gakkai zasshi
(Nippon Ganka Gakkai Zasshi)
Vol. 112
Issue 7
Pg. 590-600
(Jul 2008)
ISSN: 0029-0203 [Print] Japan |
PMID | 18702350
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Aptamers, Nucleotide
- Vascular Endothelial Growth Factor A
- pegaptanib
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Topics |
- Aged
- Aptamers, Nucleotide
(administration & dosage)
- Choroidal Neovascularization
(complications)
- Double-Blind Method
- Female
- Humans
- Injections
- Macular Degeneration
(drug therapy, physiopathology)
- Male
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
- Visual Acuity
- Vitreous Body
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