Abstract | BACKGROUND:
Tipranavir-resistance associated mutations (TPV-RAMs) are often observed among patients with HIV-1 subtype A/E infection. Data regarding TPV resistance in subtype A/E is still limited. OBJECTIVES: To determine the prevalence of TPV-RAMs among protease inhibitor-naïve, HIV-1 subtype A/E infected patients. STUDY DESIGN: Genotypic resistance testing was conducted among HIV-1-infected patients who were PI-naïve. RESULTS: We studied 112 patients (mean age, 40.7 years; 58% male). Median CD4 cell count and HIV-1 RNA were 192cells/mm(3) and 4.2logcopies/mL, respectively. Ninety-three patients (83%) infected with subtype A/E; the others had subtype B. The most common TPV-RAMs were M36I (88%), H69K (61%), and I13V (48%). Median number of TPV-RAMs was 3 mutations. Patients with subtype A/E had higher prevalence of I13V (54% vs. 21%, P=0.011), M36I (96% vs. 53%, P<0.001), H69K (68% vs. 26%, P=0.001), and >2 TPV-RAMs (62% vs. 21%, P=0.002). In multivariate analysis, only subtype A/E was associated with the occurrence of >2 TPV-RAMs (OR 9.83; 95%CI, 1.95-39.57; P=0.006). CONCLUSIONS: TPV-RAMs previously described by IAS-USA are commonly observed in PI-naïve patients with HIV-1 subtype A/E infection. Further studies to define virologic response of subtype A/E to TPV and clinical validation of TPV-RAMs in HIV-1 subtype A/E are essentially needed.
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Authors | Somnuek Sungkanuparph, Chonlaphat Sukasem, Weerawat Manosuthi, Surasak Wiboonchutikul, Bucha Piyavong, Wasun Chantratita |
Journal | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
(J Clin Virol)
Vol. 43
Issue 3
Pg. 284-6
(Nov 2008)
ISSN: 1386-6532 [Print] Netherlands |
PMID | 18701346
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-HIV Agents
- Pyridines
- Pyrones
- Sulfonamides
- HIV Protease
- p16 protease, Human immunodeficiency virus 1
- tipranavir
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Topics |
- Adult
- Anti-HIV Agents
(pharmacology)
- CD4 Lymphocyte Count
- Drug Resistance, Viral
- Female
- Genotype
- HIV Infections
(virology)
- HIV Protease
(genetics)
- HIV-1
(drug effects, genetics, isolation & purification)
- Humans
- Male
- Middle Aged
- Mutation, Missense
- Pyridines
(pharmacology)
- Pyrones
(pharmacology)
- Sulfonamides
- Viral Load
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