Sneddon-Wilkinson disease treated with etanercept: report of two cases.

Abstract

Sneddon-Wilkinson disease (SWD), also known as subcorneal pustular dermatosis, is a rare, chronic eruption that is often difficult to treat, particularly in patients who do not respond to or cannot tolerate dapsone. Few case reports exist of patients with SWD treated with antitumour necrosis factor-alpha therapy. We report two patients with SWD refractory to numerous treatments, who responded to etanercept (in combination with low-dose acitretin in one case).

• Authors: D R Berk, M A Hurt, C Mann, D Sheinbein
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 34 Issue 3 Pg. 347-51 (Apr 2009) ISSN: 1365-2230 [Electronic] England
• PMID: 18699836 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Dermatologic Agents
• Immunoglobulin G
• Receptors, Tumor Necrosis Factor
• Tumor Necrosis Factor-alpha
• Etanercept

Topics

• Adult
• Aged
• Dermatologic Agents (therapeutic use)
• Etanercept
• Female
• Humans
• Immunoglobulin G (therapeutic use)
• Male
• Middle Aged
• Receptors, Tumor Necrosis Factor (therapeutic use)
• Skin Diseases, Vesiculobullous (drug therapy, pathology)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)