Effect of cinacalcet on hypercalcemia and bone mineral density in renal transplanted patients with secondary hyperparathyroidism.

Abstract

BACKGROUND:

Persistent secondary hyperparathyroidism (SHP) is the most frequent cause of hypercalcemia observed in approximately 10% of renal transplanted (RT) patients 1 year after surgery. Persistent SHP with hypercalcemia is an important factor of bone loss after renal transplantation. This study prospectively evaluates the effects of cinacalcet therapy on serum calcium (SCa) and parathyroid hormone (PTH) blood levels, and basically on bone mineral density (BMD) in RT patients with persistent hyperparathyroidism.

METHODS:

Nine RT patients (eight women, one man) with allograft function more than 6 months were included based on total SCa more than 10.5 mg/dL and intact parathyroid hormone (iPTH) concentration more than 65 pg/mL. After inclusion, patients started on a single daily oral dose of 30 mg of cinacalcet. At inclusion and every study visit blood levels of creatinine, Ca, P, alkaline phosphatase, iPTH 1,25- dihydroxyvitamin D3, and 25-hydroxyvitamin D3 were assessed. Baseline and at the end of study radial BMD were measured. Study follow-up was 12 months.

RESULTS:

During the study period, SCa decreased from 11.72+/-0.39 to 10.03+/-0.54 mg/dL (P<0.001). iPTH decreased from 308.85+/-120.12 to 214.66+/-53.75 mg/dL (P<0.05). The mean serum creatinine decreased from 1.58+/-0.34 to 1.25+/-0.27 mg/dL (P=0.03) and the mean radial BMD increased from 0.881+/-0.155 to 0.965+/-0.123 gr/cm2 (P<0.05). There were no significant changes in the other parameters assessed. One patient was excluded for gastrointestinal intolerance.

CONCLUSIONS:

In RT patients with hypercalcemia secondary to persistent SHP, cinacalcet corrects hypercalcemia and PTH, simultaneously improving BMD.

• Authors: Carlos Bergua, José-Vicente Torregrosa, David Fuster, Alex Gutierrez-Dalmau, Federico Oppenheimer, José M Campistol
• Journal: Transplantation (Transplantation) Vol. 86 Issue 3 Pg. 413-7 (Aug 15 2008) ISSN: 0041-1337 [Print] United States
• PMID: 18698244 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Naphthalenes
• Parathyroid Hormone
• Phosphates
• Creatinine
• Alkaline Phosphatase
• Calcitriol
• Calcifediol
• Calcium
• Cinacalcet

Topics

• Administration, Oral
• Aged
• Alkaline Phosphatase (blood)
• Bone Density (drug effects)
• Calcifediol (blood)
• Calcitriol (blood)
• Calcium (blood)
• Cinacalcet
• Creatinine (blood)
• Female
• Humans
• Hypercalcemia (drug therapy, etiology, physiopathology)
• Hyperparathyroidism, Secondary (drug therapy, etiology, physiopathology)
• Kidney Transplantation (adverse effects)
• Male
• Middle Aged
• Naphthalenes (administration & dosage, adverse effects, therapeutic use)
• Parathyroid Hormone (blood)
• Phosphates (blood)
• Prospective Studies
• Time Factors
• Treatment Outcome