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Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population.

Abstract
Previous studies suggested that genetic variations in the 5' region of Epsin 4, a gene encoding enthoprotin on chromosome 5q33, are associated with schizophrenia. However, conflicting results have also been reported. We examined the possible association in a Japanese sample of 354 patients and 365 controls. Seventeen polymorphisms of Epsin 4 [3 microsatellites and 14 single nucleotide polymorphisms (SNPs)] were selected. A microsatellite marker (D5S1403) demonstrated a significant difference in the allele frequency between patients and controls (uncorrected P = 0.04). However, there was no significant difference in the genotype or allele frequency between the two groups for the other microsatellites or SNPs. Haplotype-based analysis provided no evidence for an association. The positive result at D5S1403 no longer reached statistical significance when multiple testing was taken into consideration. Our results suggest that the examined region of Epsin 4 does not have a major influence on susceptibility to schizophrenia in Japanese.
AuthorsMisty Richards, Yoshimi Iijima, Tomoko Shizuno, Yoko Kamegaya, Hiroaki Hori, Mayu Omori, Kunimasa Arima, Osamu Saitoh, Hiroshi Kunugi
JournalJournal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 115 Issue 9 Pg. 1347-54 (Sep 2008) ISSN: 0300-9564 [Print] Austria
PMID18696005 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adaptor Proteins, Vesicular Transport
  • CLINT1 protein, human
Topics
  • Adaptor Proteins, Vesicular Transport (genetics)
  • Adult
  • Asian People (genetics)
  • Brain Chemistry (genetics)
  • DNA Mutational Analysis
  • Female
  • Gene Frequency (genetics)
  • Genetic Predisposition to Disease (ethnology, genetics)
  • Genetic Testing
  • Genotype
  • Haplotypes (genetics)
  • Humans
  • Japan (epidemiology)
  • Male
  • Microsatellite Repeats (genetics)
  • Middle Aged
  • Polymorphism, Single Nucleotide (genetics)
  • Schizophrenia (epidemiology, genetics, metabolism)

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