Abstract |
The Val-Val-Tyr-Pro-Asp bone marrow peptide (MP-5) and an analogue (MP-5-Lys) were synthesized. Fluorescent derivatives, Ftc-MP-5 and MP-5-Lys(Ftc), were prepared. The biological activity of MP-5 and MP-5-Lys was studied in vitro and in vivo. The MP-5 peptide caused 60-84% inhibition of growth of the following mouse cancers: lymphatic leukemia P-388, melanoma B-16, and cervical carcinoma CUC-5. These peptides also restored functional activity of T lymphocytes that was inhibited by metabolic products of the HL-60 leukemic cell line. MP-5-Lys(Ftc) was shown to preserve the functional properties of MP-5 toward T lymphocytes, but Ftc-MP-5 was practically inactive.
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Authors | L A Fonina, A A Az'muko, V N Kalikhevich, M L Levit, Z A Ardemasova, S A Gur'ianov, R G Belevskaia, M A Efremov, E M Treshchalina, A A Mikhaĭlova |
Journal | Bioorganicheskaia khimiia
(Bioorg Khim)
2008 Jul-Aug
Vol. 34
Issue 4
Pg. 451-6
ISSN: 0132-3423 [Print] Russia (Federation) |
PMID | 18695716
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Fluorescent Dyes
- Immunologic Factors
- Oligopeptides
- myelopeptides
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Topics |
- Animals
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Fluorescent Dyes
(chemical synthesis, chemistry, pharmacology)
- Immunologic Factors
(chemical synthesis, chemistry, pharmacology)
- Mice
- Oligopeptides
(chemical synthesis, chemistry, pharmacology)
- T-Lymphocytes
(cytology, drug effects, immunology)
- Xenograft Model Antitumor Assays
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