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[Myelopeptide MP-5 and fluorescent derivatives: synthesis and biological activity].

Abstract
The Val-Val-Tyr-Pro-Asp bone marrow peptide (MP-5) and an analogue (MP-5-Lys) were synthesized. Fluorescent derivatives, Ftc-MP-5 and MP-5-Lys(Ftc), were prepared. The biological activity of MP-5 and MP-5-Lys was studied in vitro and in vivo. The MP-5 peptide caused 60-84% inhibition of growth of the following mouse cancers: lymphatic leukemia P-388, melanoma B-16, and cervical carcinoma CUC-5. These peptides also restored functional activity of T lymphocytes that was inhibited by metabolic products of the HL-60 leukemic cell line. MP-5-Lys(Ftc) was shown to preserve the functional properties of MP-5 toward T lymphocytes, but Ftc-MP-5 was practically inactive.
AuthorsL A Fonina, A A Az'muko, V N Kalikhevich, M L Levit, Z A Ardemasova, S A Gur'ianov, R G Belevskaia, M A Efremov, E M Treshchalina, A A Mikhaĭlova
JournalBioorganicheskaia khimiia (Bioorg Khim) 2008 Jul-Aug Vol. 34 Issue 4 Pg. 451-6 ISSN: 0132-3423 [Print] Russia (Federation)
PMID18695716 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Fluorescent Dyes
  • Immunologic Factors
  • Oligopeptides
  • myelopeptides
Topics
  • Animals
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Fluorescent Dyes (chemical synthesis, chemistry, pharmacology)
  • Immunologic Factors (chemical synthesis, chemistry, pharmacology)
  • Mice
  • Oligopeptides (chemical synthesis, chemistry, pharmacology)
  • T-Lymphocytes (cytology, drug effects, immunology)
  • Xenograft Model Antitumor Assays

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