[Effect of alkylating chemical substances on the activity and molecular heterogeneity of mouse sarcoma 180 nucleoside phosphate kinases].

Abstract

The fractionation of extracts from sarcoma 180 cells was carried out on DEAE-cellulose following the administration to tumor-bearing mice of one of chloroctyl amino-phenildioxan derivatives. The tumor regression was noted more than in 50 per cent. It was found that the tumor regression, caused by this alkylating agent, results in marked changes in the fractionation pattern of thymidilatkinases. The origin of these changes is being discussed.

• Authors: A V Tret'iakov, A G Mukhlenov
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 22 Issue 7 Pg. 65-7 ( 1976) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie alkiliruiushchikh khimiopreparatov na aktivnost' i molekuliarnuiu geterogennost' nukleozidfosfatkinaz sarkomy 180 mysheĭ
• PMID: 186952 (Publication Type: English Abstract, Journal Article)

Chemical References

• Alkylating Agents
• Phosphotransferases
• Nucleoside-Phosphate Kinase
• Nucleoside-Diphosphate Kinase

Topics

• Alkylating Agents (therapeutic use)
• Animals
• Mice
• Nucleoside-Diphosphate Kinase (metabolism)
• Nucleoside-Phosphate Kinase (metabolism)
• Phosphotransferases (metabolism)
• Sarcoma 180 (drug therapy, enzymology)