Induction of allergic contact dermatitis by astigmatid mite-derived monoterpene, alpha-acaridial.

Abstract

alpha-Acaridial [2(E)-(4-methyl-3-pentenyl)butenedial] is a novel monoterpene secreted from the house dust mites. Because of its molecular nature of a highly reactive, small lipidic compound, we addressed whether alpha-acaridial might function as a haptenic allergen that induced allergic contact dermatitis. Mice sensitized with alpha-acaridial were challenged by the same antigen on the ear skin. After 2 days, significant ear swelling with a prominent infiltration of CD4(+) T lymphocytes was observed. In vitro, alpha-acaridial exhibited an outstanding ability to quickly interact with and chemically modify a reference protein. Virtually all cysteine residues and a sizable fraction of lysine residues were found to be selectively modified, suggesting that alpha-acaridial could potentially interact with any proteins. Previously, numerous mite-derived proteinaceous allergens have been associated with contact dermatitis. Our study now emphasizes that small lipidic compounds released from mites comprise a new class of mite allergens, and therefore, is of significant medical implications.

• Authors: Toshio Sasai, Yunosuke Hirano, Sayaka Maeda, Isamu Matsunaga, Atsushi Otsuka, Daisuke Morita, Ritsuo Nishida, Hideo Nakayama, Yasumasa Kuwahara, Masahiko Sugita, Naoki Mori
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 375 Issue 3 Pg. 336-40 (Oct 24 2008) ISSN: 1090-2104 [Electronic] United States
• PMID: 18694730 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aldehydes
• Antigens, Dermatophagoides
• Monoterpenes
• beta-acaridial

Topics

• Aldehydes (chemistry, immunology)
• Animals
• Antigens, Dermatophagoides (chemistry, immunology)
• CD4-Positive T-Lymphocytes (immunology)
• Dermatitis, Allergic Contact (immunology)
• Disease Models, Animal
• Female
• Mice
• Mice, Inbred BALB C
• Monoterpenes (chemistry, immunology)