HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Huang-Lian-Jie-Du-Tang inhibits myocardial remodeling in a rat model of metabolic syndrome.

Abstract
Huang-Lian-Jie-Du-Tang (HLJDT) is a traditional Chinese herbal medicine and a potential anti-inflammatory agent. HLJDT has been used successfully to treat inflammation in diabetic rats. The current study is aimed to evaluate the effectiveness of HLJDT on myocardial remodeling in a rat model of metabolic syndrome (MS). Twenty-one MS rats were divided into two groups: the MS group and the MS+HLJDT group. Ten Wister rats were a normal control group (NC group). HLJDT (1.04 g/100g) was orally administered daily for 12 weeks in the MS+HLJDT group. The trial lasted 12 weeks. Changes of echocardiography, histological staining, transmission electron microscope (TEM), and molecular biology examinations were made. After treatment, in the MS+HLJDT group, Masson staining and echocardiography data revealed decreased collagen fibers compared with the MS group. Messenger RNA levels of IL-6, ICAM-1, TNF-alpha, TGF-beta1, NF-kappaB in left ventricular tissues were lower than in the MS group, and volume of mitochondria and the phenotype of cardiac muscle cells in TEM were close to normal. The results suggested that HLJDT reduced myocardial collagen deposition and inhibited cardiac remodeling in a rat model of MS.
AuthorsXiaoxing Li, Chuanbao Li, Xiaoping Ji, Zhaofeng Song, Lihong Wang, Juan Zhang, Yun Zhang
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 119 Issue 2 Pg. 259-65 (Sep 26 2008) ISSN: 0378-8741 [Print] Ireland
PMID18692559 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Drugs, Chinese Herbal
  • Inflammation Mediators
  • RNA, Messenger
  • oren gedoku to
  • Collagen
Topics
  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Collagen (drug effects, metabolism)
  • Disease Models, Animal
  • Drugs, Chinese Herbal (pharmacology)
  • Echocardiography
  • Inflammation Mediators (metabolism)
  • Male
  • Metabolic Syndrome (drug therapy)
  • Microscopy, Electron, Transmission
  • RNA, Messenger (drug effects, metabolism)
  • Rats
  • Rats, Wistar
  • Ventricular Remodeling (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: