Abstract | BACKGROUND: Measurement of concentrations of acute-phase proteins (APPs) is used as an aid in the diagnosis of a variety of diseases in animals. OBJECTIVE: ANIMALS: One hundred and thirty-three dogs with neurologic diseases, 6 dogs with sepsis, and 8 healthy dogs were included in the study. Thirty-six dogs had SRMA (31 of which had monitoring), 14 dogs had other meningoencephalitides (ME), 32 had disk disease (IVDD/DLSS), 26 had tumors affecting the central nervous system (TCNS), and 25 had idiopathic epilepsy (IE). METHODS: Prospective, observational study: C-reactive protein (CRP), alpha(2)-macroglobulin (AMG), and albumin concentrations were determined in the serum or plasma. CRP was also measured in the cerebrospinal fluid. RESULTS: Serum CRP was significantly higher in dogs with SRMA (x=142 microg/mL+/-75) and sepsis (x=114 microg/mL+/-67) in comparison with dogs with other neurologic diseases (x=2.3-21 microg/mL; P< .001). There was no significant difference detected in AMG between groups. Serum albumin concentration was significantly lower (P< .01) in dogs with SRMA (x=3.2 g/dL+/-0.41) than in other groups (x=3.6-3.9 g/dL). Serum CRP concentration of SRMA dogs correlated with alkaline phosphatase levels (r=0.515, P= .003). CONCLUSIONS AND CLINICAL IMPORTANCE: CRP concentrations in serum are useful in diagnosis of dogs with SRMA. Serum CRP could be used as a monitoring parameter in treatment management of these dogs.
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Authors | A Bathen-Noethen, R Carlson, D Menzel, R Mischke, A Tipold |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
2008 Sep-Oct
Vol. 22
Issue 5
Pg. 1149-56
ISSN: 0891-6640 [Print] United States |
PMID | 18691368
(Publication Type: Journal Article)
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Chemical References |
- Acute-Phase Proteins
- Adrenal Cortex Hormones
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Topics |
- Acute-Phase Proteins
(analysis, metabolism)
- Adrenal Cortex Hormones
(therapeutic use)
- Animals
- Arteritis
(cerebrospinal fluid, drug therapy, metabolism, veterinary)
- Central Nervous System
(immunology)
- Cerebrospinal Fluid
(chemistry)
- Dog Diseases
(blood, immunology)
- Dogs
- Female
- Male
- Meninges
(blood supply)
- Meningitis
(cerebrospinal fluid, drug therapy, metabolism, veterinary)
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