Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture.

Abstract

After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 mug/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.

• Authors: Taek Joon Yoon, Kwang-Won Yu, Kwang-Soon Shin, Hyung Joo Suh
• Journal: Applied microbiology and biotechnology (Appl Microbiol Biotechnol) Vol. 80 Issue 6 Pg. 1087-93 (Oct 2008) ISSN: 1432-0614 [Electronic] Germany
• PMID: 18690428 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunologic Factors
• Polymers

Topics

• Animals
• Cell Line, Tumor
• Cordyceps (immunology, metabolism)
• Female
• Immunity, Innate (drug effects)
• Immunologic Factors (isolation & purification, metabolism, pharmacology)
• Killer Cells, Natural (immunology)
• Leukocyte Reduction Procedures
• Mice
• Mice, Inbred BALB C
• Neoplasm Metastasis (prevention & control)
• Neoplasms (immunology)
• Polymers (isolation & purification, metabolism, pharmacology)