Solid organ and hematopoietic stem cell transplant recipients are more likely to develop skin and
soft tissue infections, which may be caused by common or atypical pathogens. Skin and soft tissue anatomic abnormalities may act as portals of entry for
infection, and may result from surgery, venous access, immunosuppressive medications, and other etiologies. Systemic
infection may sometimes be recognized by investigation of
skin manifestations. Many noninfectious processes of the skin and soft tissues can mimic
infection, complicating the diagnosis. Prompt dermatologic consultation and skin biopsy are essential in this vulnerable population. Treatment of
infection in transplant recipients may necessitate reduction of immunosuppression, in addition to other adjunctive
therapies. Interesting and important new findings about skin and
soft tissue infections in transplant recipients are the focus of this review.