Abstract | BACKGROUND: METHODS: We measured D(1) receptor binding using [(11)C]- SCH23390 and PET in 12 subjects with the alpha4-Ser248Phe mutation (3 men, mean age 41 +/- 16 years) and 19 controls (8 men, mean age 36 +/- 13 years) matched for gender, smoking status, and age. Parametric images were produced using the simplified reference region method. Both MRI-based regions of interest and voxel based analyses were used. RESULTS: Reduced striatal [(11)C]- SCH23390 binding occurred with the mutation (controls 1.1 +/- 0.1; ADNFLE 0.97 +/- 0.2; p < 0.01). Statistical parametric mapping confirmed a region of reduced [(11)C]- SCH23390 binding in the right putamen in alpha4-Ser248Phe subjects compared to controls (309 voxels, local maxima 20 16 -2 mm; Z(score) 3.57, p < 0.05). CONCLUSIONS:
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Authors | M Fedi, S F Berkovic, I E Scheffer, G O'Keefe, C Marini, R Mulligan, S Gong, H Tochon-Danguy, D C Reutens |
Journal | Neurology
(Neurology)
Vol. 71
Issue 11
Pg. 795-8
(Sep 09 2008)
ISSN: 1526-632X [Electronic] United States |
PMID | 18685138
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Corpus Striatum
(metabolism)
- Epilepsy, Frontal Lobe
(genetics, metabolism)
- Female
- Genes, Dominant
(genetics)
- Humans
- Male
- Middle Aged
- Nocturnal Paroxysmal Dystonia
(genetics, metabolism)
- Positron-Emission Tomography
(methods)
- Protein Binding
(physiology)
- Receptors, Dopamine D1
(antagonists & inhibitors, metabolism)
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