Treatment of chemically induced autochthonous rat mammary and colorectal carcinomas with interleukin-2.

Abstract	The antineoplastic efficacy of human interleukin-2 (IL-2) in autochthonous methylnitrosourea-induced mammary carcinoma and in acetoxymethyl-methyl-nitrosamine-induced colorectal carcinoma of Sprague Dawley rats has been investigated. Under the conditions applied, IL-2 was non-toxic. In the mammary carcinoma IL-2 was therapeutically inactive. In the colorectal carcinoma, 1200 U IL-2/day exhibited significant antitumour activity in established tumours as well as in tumours treated "prophylactically" before their manifestation (P less than 0.05). The effect of IL-2 seemed to be more pronounced when given before manifestation of colorectal tumours (T/C = 8.7% vs 17.8% in established tumours). The differential sensitivity of the autochthonous mammary and colorectal carcinoma may be explained by differences in their proliferation rates and differences in volumes at the beginning of IL-2 therapy. IL-2 seems to be preferentially active in small tumours with a low proliferation rate, a feature typical of colon tumours.
Authors	M R Berger, M Salas, F Garzon, E Petru, U Schwulera, D Schmähl
Journal	Cancer immunology, immunotherapy : CII (Cancer Immunol Immunother) Vol. 33 Issue 5 Pg. 346-9 ( 1991) ISSN: 0340-7004 [Print] Germany
PMID	1868493 (Publication Type: Journal Article)
Chemical References	Antineoplastic Agents Carcinogens Interleukin-2 methyl(acetoxymethyl)nitrosamine mafosfamide Methylnitrosourea Cyclophosphamide Dimethylnitrosamine
Topics	Animals Antineoplastic Agents (administration & dosage) Antineoplastic Combined Chemotherapy Protocols (pharmacology) Carcinogens Colorectal Neoplasms (chemically induced, drug therapy) Cyclophosphamide (administration & dosage, analogs & derivatives) Dimethylnitrosamine (analogs & derivatives) Female Interleukin-2 (administration & dosage, pharmacology) Male Mammary Neoplasms, Experimental (chemically induced, drug therapy) Methylnitrosourea Neoplasm Transplantation Rats Rats, Inbred Strains

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