A lufenuron pre-treatment may enhance the effects of enilconazole or griseofulvin in feline dermatophytosis?

Abstract

The effectiveness of enilconazole (4 weekly rinses with a 0.2% solution) or griseofulvin (50mg/kg twice daily for 40 days) following a pre-treatment with oral lufenuron (100mg/kg by-weekly for 8 weeks) was tested on 25 (11+14) Microsporum canis infected cats. Control animals were treated with lufenuron, griseofulvin and enilconazole alone. At day 150 pre-treated animals were culturally negative and clinically cured. While lufenuron alone was found to be ineffective against M canis infection, an immunomodulatory effect of the drug can be suggested, as reported in literature. Its use could be reserved to long-lasting infections, unsuccessfully treated with conventional drugs. Further studies are required to clearly establish the possible adjuvant effect of this molecule when used prior to enilconazole or griseofulvin.

• Authors: Francesca Mancianti, Sara Dabizzi, Simona Nardoni
• Journal: Journal of feline medicine and surgery (J Feline Med Surg) Vol. 11 Issue 2 Pg. 91-5 (Feb 2009) ISSN: 1098-612X [Print] England
• PMID: 18684653 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antifungal Agents
• Benzamides
• Fungicides, Industrial
• Imidazoles
• Insecticides
• fluphenacur
• Griseofulvin
• enilconazole

Topics

• Animals
• Antifungal Agents (therapeutic use)
• Benzamides (therapeutic use)
• Cat Diseases (drug therapy, microbiology)
• Cats
• Dermatomycoses (drug therapy, microbiology, veterinary)
• Drug Therapy, Combination
• Female
• Fungicides, Industrial (therapeutic use)
• Griseofulvin (therapeutic use)
• Imidazoles (therapeutic use)
• Insecticides (therapeutic use)
• Male
• Microsporum (drug effects, isolation & purification)