Abstract | CONTEXT: OBJECTIVES: To identify clinicopathologic features of tumors associated with PIgR expression and to determine whether PIgR expression is associated with intestinal differentiation of tumors and intestinal metaplasia in background mucosa in 3 groups of upper gastrointestinal adenocarcinomas. These groups are (1) gastric adenocarcinomas, (2) adenocarcinomas of the distal esophagus and GE junction with background intestinal metaplasia, and (3) adenocarcinomas of the distal esophagus and GE junction without background intestinal metaplasia. DESIGN: Expression of PIgR and CDX2 in nonneoplastic mucosa, intestinal metaplasia, and adenocarcinomas was examined by immunohistochemistry in 42 cases: 14 gastric and 28 from the distal esophagus and GE junction, including 13 with esophageal or GE junction intestinal metaplasia. RESULTS: PIgR and CDX2 were expressed in all cases of intestinal metaplasia. PIgR expression was positive in 40% of group 3 versus 77% of group 2 and 71% of gastric adenocarcinomas (P = .06), and the expression of CDX2 was similar in all tumor groups (80%-83%). Metastatic-positive lymph nodes were more frequent in PIgR-negative tumors (94% vs 58%, P = .01). CONCLUSIONS:
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Authors | Adrian Gologan, Marie Acquafondata, Rajiv Dhir, Antonia R Sepulveda |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 132
Issue 8
Pg. 1295-301
(Aug 2008)
ISSN: 1543-2165 [Electronic] United States |
PMID | 18684029
(Publication Type: Journal Article)
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Chemical References |
- CDX2 Transcription Factor
- CDX2 protein, human
- Homeodomain Proteins
- Receptors, Polymeric Immunoglobulin
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Topics |
- Adenocarcinoma
(chemistry, pathology, secondary)
- Aged
- CDX2 Transcription Factor
- Esophageal Neoplasms
(chemistry, pathology)
- Esophagogastric Junction
- Female
- Homeodomain Proteins
(analysis)
- Humans
- Immunohistochemistry
(methods)
- Intestines
(pathology)
- Lymphatic Metastasis
- Male
- Metaplasia
- Middle Aged
- Neoplasm Staging
- Receptors, Polymeric Immunoglobulin
(analysis)
- Staining and Labeling
- Stomach Neoplasms
(chemistry, pathology)
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