Radioprotective effects of fucoidan in mice treated with total body irradiation.

Abstract

The effects of fucoidan on the survival rate of mice treated with total body irradiation were examined. BALB/c mice were pretreated with various doses of fucoidan prior to total-body irradiation and were monitored for 30 days. A significant improvement of survival was observed by pretreatment with fucoidan at 100 mg/kg body weight. Using this optimal dosage, survival was examined by radiation dose reduction analysis and a dose reduction factor (DRF) of 1.20 was determined at 30 days post-irradiation. Mice pretreated with fucoidan also exhibited dose-dependent increases in the number of bone marrow cells and endogenous spleen cell colonies at day 9 post-irradiation. It is concluded that the increased survival of whole-body irradiated mice pretreated with fucoidan may be attributable to the radioprotective effects of fucoidan on hematopoietic cell viability, proliferation and/or mobility, possibly through antioxidation or antiinflammatory mechanisms.

• Authors: Jeeyoung Lee, Jeongtae Kim, Changjong Moon, Sung-Ho Kim, Jin Won Hyun, Jae Woo Park, Taekyun Shin
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 22 Issue 12 Pg. 1677-81 (Dec 2008) ISSN: 1099-1573 [Electronic] England
• PMID: 18683851 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2008 John Wiley & Sons, Ltd.

Chemical References

• Polysaccharides
• Radiation-Protective Agents
• fucoidan

Topics

• Analysis of Variance
• Animals
• Dose-Response Relationship, Drug
• Female
• Gamma Rays
• Hematopoietic Stem Cells (drug effects, radiation effects)
• Mice
• Mice, Inbred BALB C
• Phaeophyta (chemistry)
• Polysaccharides (pharmacology)
• Radiation-Protective Agents (pharmacology)
• Spleen (drug effects, radiation effects)
• Survival Rate
• Whole-Body Irradiation