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Diffusion-weighted MRI of denervated muscle: a clinical and experimental study.

AbstractOBJECTIVE:
The aim of this study was to investigate skeletal muscle denervation using diffusion-weighted magnetic resonance imaging (DWMRI).
MATERIALS AND METHODS:
Sciatic nerve axotomy was performed in a group of nine New Zealand White rabbits, and electromyographic (EMG), pathological, and DWMRI studies were conducted on ipsilateral hamstring muscles 1 and 8 days after axotomy. In addition, DWMRI studies were carried out on leg muscles of ten patients with acute and subacute lumbosacral radiculopathy.
RESULTS:
High intensity signals on short tau inversion recovery (STIR) magnetic resonance imaging and an increased apparent diffusion coefficient (ADC) were observed in denervated muscles of the animals 1 and 8 days after axotomy as well as in denervated muscles of the patients with radiculopathy. In the clinical study, ADC was 1.26 +/- 0.18 x 10(-9) m(2)/s in normal muscle and increased to 1.56 +/- 0.23 x 10(-9) m(2)/s in denervated muscles (p = 0.0016). In animals, EMG and muscle pathological studies were normal 1 day after axotomy, and the muscles demonstrated spontaneous activity on EMG and neurogenic atrophy on histological studies 7 days later.
CONCLUSION:
This DWMRI study demonstrates that enlargement of extracellular fluid space in muscle denervation is an early phenomenon occurring several days before the appearance of EMG and histological abnormalities.
AuthorsNathalie Holl, Andoni Echaniz-Laguna, Guillaume Bierry, Michel Mohr, Jean-Philippe Loeffler, Thomas Moser, Jean-Louis Dietemann, Stéphane Kremer
JournalSkeletal radiology (Skeletal Radiol) Vol. 37 Issue 12 Pg. 1111-7 (Dec 2008) ISSN: 0364-2348 [Print] Germany
PMID18682930 (Publication Type: Journal Article)
Chemical References
  • Contrast Media
  • Organometallic Compounds
  • Meglumine
  • gadoterate meglumine
Topics
  • Adult
  • Animals
  • Biopsy
  • Contrast Media
  • Diffusion Magnetic Resonance Imaging (methods)
  • Electromyography (methods)
  • Extracellular Fluid
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Leg (innervation)
  • Lumbosacral Region (pathology)
  • Male
  • Meglumine
  • Middle Aged
  • Models, Animal
  • Muscle Denervation
  • Muscle, Skeletal (innervation, pathology)
  • Observer Variation
  • Organometallic Compounds
  • Rabbits
  • Radiculopathy (pathology)
  • Sciatic Nerve

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