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Effect of oxazolidinone, RBx 7644 (ranbezolid), on inhibition of staphylococcal adherence to plastic surfaces.

Abstract
Adhesion to biomaterial is assumed to be a crucial step in the pathogenesis of foreign body infection. Slime producing Staphylococcus epidermidis and Staphylococcus aureus have emerged as a preeminent cause of nosocomial bacteremia and infections of prosthetic medical devices. We evaluated the time-dependent anti-adhesive effect of RBx 7644 (ranbezolid), vancomycin, linezolid and quinupristin/ dalfopristin on two isolates each of S. epidermidis and S. aureus. Linezolid and quinupristin/ dalfopristin showed inhibition only at supra-inhibitory concentrations (2 and 4X MIC) following 2 and 4 h delayed treatment, whereas RBx 7644 demonstrated significant activity against adhesion of staphylococcal cells that had been treated with 2 to 6 h delay. When vancomycin treatment was delayed by 4 to 6 h, even concentrations above the MIC were unable to prevent adherence. This study indicates that RBx 7644 has anti-adhesion potential and may emerge as an important antibiotic for prevention and treatment of device-related infections caused by staphylococci.
AuthorsT Mathur, S Singhal, S Khan, P Bhateja, M Pandya, A Rattan, P K Bhatnagar, D J Upadhyay, T Fatma
JournalJournal of chemotherapy (Florence, Italy) (J Chemother) Vol. 20 Issue 4 Pg. 420-7 (Aug 2008) ISSN: 1973-9478 [Electronic] England
PMID18676219 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Acetamides
  • Anti-Bacterial Agents
  • Furans
  • Oxazoles
  • Oxazolidinones
  • Plastics
  • ranbezolid
  • Virginiamycin
  • quinupristin-dalfopristin
  • Vancomycin
  • Linezolid
Topics
  • Acetamides (pharmacology)
  • Anti-Bacterial Agents (pharmacology)
  • Bacterial Adhesion (drug effects)
  • Biofilms (drug effects)
  • Dose-Response Relationship, Drug
  • Furans (pharmacology)
  • Linezolid
  • Microbial Sensitivity Tests
  • Oxazoles (pharmacology)
  • Oxazolidinones (pharmacology)
  • Plastics
  • Staphylococcus aureus (drug effects, growth & development)
  • Staphylococcus epidermidis (drug effects, growth & development)
  • Time Factors
  • Vancomycin (pharmacology)
  • Virginiamycin (pharmacology)

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