Carbimazole embryopathy-bilateral choanal atresia and patent vitello-intestinal duct: a case report and review of literature.

Abstract

BACKGROUND:

In utero exposure to carbimazole for maternal hyperthyroidism has been reported to cause choanal atresia. There are case reports of patent vitello-intestinal duct and Meckel's diverticulum in similar association.

CASE:

We report another such instance of an infant who was exposed to carbimazole in utero, presenting with bilateral choanal atresia and patent vitello-intestinal duct.

CONCLUSIONS:

As there seems to be no reports of a possible association between propylthiouracil and congenital malformations, it may be safer to use propylthiouracil instead of carbimazole.

• Authors: Lakshminarayanan Kannan, Satish Mishra, Ramesh Agarwal, Venkat Kartikeyan, Neerja Gupta, Madhulika Kabra
• Journal: Birth defects research. Part A, Clinical and molecular teratology (Birth Defects Res A Clin Mol Teratol) Vol. 82 Issue 9 Pg. 649-51 (Sep 2008) ISSN: 1542-0760 [Electronic] United States
• PMID: 18671255 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: (c) 2008 Wiley-Liss, Inc.

Chemical References

• Antithyroid Agents
• Carbimazole

Topics

• Abnormalities, Drug-Induced (embryology)
• Antithyroid Agents (adverse effects)
• Carbimazole (adverse effects)
• Choanal Atresia (chemically induced, embryology, surgery)
• Female
• Humans
• Infant
• Male
• Pregnancy
• Vitelline Duct (abnormalities, embryology)