Marek's disease vaccines cause temporary U-lymphocyte dysfunction and reduced resistance to infection in chicks.

Abstract

One-day-old chicks were vaccinated with one of the commercially used vaccines [herpes virus of turkeys (HVT), bivalent HVT+SB1 or Rispens] and the immune response and resistance to infection evaluated. A temporary depletion of B-lymphocyte activity of varying intensity was found, as demonstrated by a diminished response to a B-lymphocyte-specific mitogen in vitro, and by decreased antibody production to BSA in vivo. Of the three vaccines tested, the bivalent vaccine (HVT+SB1) and Rispens were the most damaging. A temporary decreased resistance to pathogenic E coli infection in vaccinated chicks was observed.

• Authors: A Friedman, E Shalem-Meilin, E D Heller
• Journal: Avian pathology : journal of the W.V.P.A (Avian Pathol) Vol. 21 Issue 4 Pg. 621-31 (Dec 1992) ISSN: 0307-9457 [Print] England
• PMID: 18670980 (Publication Type: Journal Article)