Abstract | OBJECTIVE: METHODS: Two patients with stage 5 chronic kidney disease and NSF were treated with oral imatinib mesylate at a dosage of 400 mg/day. Skin thickening and tethering were assessed using the modified Rodnan skin thickness score (MRSS), and knee joint flexion contractures were measured with a goniometer. RESULTS: Each patient displayed progressive reduction of skin thickening and tethering, with a steady decrease in the MRSS, following the initiation of imatinib mesylate treatment. The patient who had knee joint contractures achieved increased knee extension with passive range-of-motion exercises once his skin thickening and tethering had begun to decrease. Within weeks of stopping imatinib mesylate, the skin changes recurred in each patient. Recurrent skin thickening and tethering again improved in the patient who resumed taking imatinib mesylate for longer than 2 weeks. Skin biopsies performed both before and after initial dosing of that patient revealed less fibrosis and less staining for type I procollagen after imatinib mesylate treatment, but essentially unchanged tissue gadolinium content. CONCLUSION:
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Authors | Jonathan Kay, Whitney A High |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 58
Issue 8
Pg. 2543-8
(Aug 2008)
ISSN: 0004-3591 [Print] United States |
PMID | 18668587
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Benzamides
- Piperazines
- Protein Kinase Inhibitors
- Pyrimidines
- Imatinib Mesylate
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Topics |
- Aged
- Benzamides
- Fibrosis
- Humans
- Imatinib Mesylate
- Kidney Diseases
(drug therapy, physiopathology)
- Knee Joint
(drug effects, physiopathology)
- Male
- Piperazines
(therapeutic use)
- Protein Kinase Inhibitors
(therapeutic use)
- Pyrimidines
(therapeutic use)
- Scleroderma, Systemic
(drug therapy, physiopathology)
- Skin
(drug effects, physiopathology)
- Treatment Outcome
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