Dietary red chilli (Capsicum frutescens L.) is insulinotropic rather than hypoglycemic in type 2 diabetes model of rats.

Abstract

The present study was conducted to clarify whether a low or a high, but tolerable, dietary dose of red chilli (RC) can ameliorate the diabetes related complications in a high-fat (HF) diet-fed streptozotocin (STZ)-induced type 2 diabetes model of rats. Five-week-old male Sprague Dawley rats were fed a HF diet for 2 weeks then randomly divided into four groups namely: normal control (NC), diabetic control (DBC), red chilli low (RCL, 0.5%) and red chilli high (RCH, 2.0%) groups. Diabetes was induced by an intraperitoneal (i.p.) injection of STZ (40 mg/kg BW) in all groups except the NC group. After 4 weeks feeding of experimental diets, the fasting blood glucose concentrations in both RC fed groups were not significantly different. The serum insulin concentration was significantly (p < 0.05) increased in the RCH group compared with the DBC and RCL groups. Blood HbA1c, liver weight, liver glycogen and serum lipids were not influenced by the feeding of RC-containing diets. The data of this study suggest that 2% dietary RC is insulinotropic rather than hypoglycemic at least in this experimental condition.

• Authors: Md Shahidul Islam, Haymie Choi
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 22 Issue 8 Pg. 1025-9 (Aug 2008) ISSN: 1099-1573 [Electronic] England
• PMID: 18668490 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Dietary Fats
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Insulin
• Liver Glycogen
• Plant Extracts

Topics

• Animal Feed
• Animals
• Blood Glucose (analysis)
• Capsicum (chemistry)
• Diabetes Mellitus, Experimental (blood, diet therapy)
• Diabetes Mellitus, Type 2 (blood, diet therapy)
• Diet
• Dietary Fats
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Food Deprivation (physiology)
• Glucose Tolerance Test
• Glycated Hemoglobin (analysis)
• Hypoglycemic Agents (classification, pharmacology)
• Insulin (blood, physiology)
• Liver (drug effects, metabolism, pathology)
• Liver Glycogen (analysis, metabolism)
• Male
• Organ Size (drug effects)
• Plant Extracts (classification, pharmacology)
• Rats
• Rats, Sprague-Dawley