Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002.

Abstract

Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

• Authors: Mohamed S Abdelfattah, Madan Kumar Kharel, John Andrew Hitron, Irfan Baig, Jürgen Rohr
• Journal: Journal of natural products (J Nat Prod) Vol. 71 Issue 9 Pg. 1569-73 (Sep 2008) ISSN: 1520-6025 [Electronic] United States
• PMID: 18666798 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Anthraquinones
• Antibiotics, Antineoplastic
• moromycin A
• moromycin B

Topics

• Anthraquinones (chemistry, isolation & purification, pharmacology)
• Antibiotics, Antineoplastic (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Female
• Humans
• Kentucky
• Microbial Sensitivity Tests
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Streptomyces (chemistry)