[Effects of different Chinese herbal medicines on biochemical parameters in guinea-pig with pigment gallstones].

Abstract

OBJECTIVE:

To observe the effects of Qingdan Capsule (QDC) and Yanggan Lidan Granule (YGLDG), two kinds of compound traditional Chinese herbal medicines, on biochemical parameters in guinea-pigs with pigment gallstones.

METHODS:

An animal model of pigment gallstones was established in male guinea-pigs by hypodermic injection of lincomycin. The guinea-pigs were randomly divided into blank control group, untreated group, QDC group and YGLDG group. There were 8 guinea-pigs in each group. After ten-day treatment, animals were sacrificed and sampled to calculate the rate of stone formation, total bilirubin (TB), unconjugated bilirubin (UCB) and Ca2+ density in bile of the four groups.

RESULTS:

In comparison with the untreated group, the rates of stone formation in the QDC and YGLDG groups were significantly decreased (P<0.01). TBIL, UCB and Ca2+ content of bile in both QDC and YGLD groups was also significantly decreased (P<0.05, P<0.01).

CONCLUSION:

QDC and YGLD have good effects on biochemical changes of animal model of pigment gallstone in reversing the lithogenesity of bile by reducing the content of TB, UCB and Ca2+, hence resulting in clinical treatment and prevention of pigment gallstone disease.

• Authors: Jing-zhe Zhang, Xue-lin Zhang, Xiao-qiang Liang, Hong-gang Gu, Pei-ting Zhu
• Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine (Zhong Xi Yi Jie He Xue Bao) Vol. 6 Issue 8 Pg. 856-9 (Aug 2008) ISSN: 1672-1977 [Print] China
• PMID: 18664357 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bile Pigments
• Cholagogues and Choleretics
• Drugs, Chinese Herbal
• Lincomycin
• Calcium

Topics

• Animals
• Bile Pigments (metabolism)
• Calcium (metabolism)
• Cholagogues and Choleretics (therapeutic use)
• Drugs, Chinese Herbal (therapeutic use)
• Gallstones (chemically induced, chemistry, drug therapy)
• Guinea Pigs
• Lincomycin
• Male
• Phytotherapy
• Random Allocation