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Role of gemifloxacin in community-acquired pneumonia.

Abstract
Community-acquired pneumonia (CAP) is the leading cause of death due to bacterial infection. It accounts for 10 million physician office visits in the USA annually. However, 80% of these are managed in the community, usually with oral antibiotic therapy. Typically, such courses have lasted 10 days or longer. Streptococcus pneumoniae accounts for 25% of all CAP infections; resistance among S. pneumoniae to all classes of antibiotics, including fluoroquinolones, poses new and shifting challenges to the primary care physician. Gemifloxacin is a potent agent, active against pneumococci and atypical pathogens. Administered once daily for 5 days, gemifloxacin is highly efficacious and well tolerated. Gemifloxacin administered for 5-7 days is a cost effective and safe alternative to both parenteral and oral antimicrobials, which may not cover the emerging resistant respiratory pathogens.
AuthorsGlenn S Tillotson
JournalExpert review of anti-infective therapy (Expert Rev Anti Infect Ther) Vol. 6 Issue 4 Pg. 405-18 (Aug 2008) ISSN: 1744-8336 [Electronic] England
PMID18662107 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Bacterial Agents
  • Fluoroquinolones
  • Naphthyridines
  • Gemifloxacin
Topics
  • Anti-Bacterial Agents (therapeutic use)
  • Community-Acquired Infections (drug therapy, economics, epidemiology)
  • Drug Resistance, Bacterial
  • Fluoroquinolones (therapeutic use)
  • Gemifloxacin
  • Humans
  • Naphthyridines (therapeutic use)
  • Pneumonia, Bacterial (drug therapy, economics, epidemiology)

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