Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB.

Abstract

This study investigated whether abnormalities in serotonin transporter binding occur in Parkinson's disease (PD) patients with concurrent depression. We estimated serotonin transporter levels in seven clinically depressed early-stage PD patients and in seven healthy matched-control subjects during a single positron emission tomography (PET) scan with the serotonin transporter radioligand, [(11)C]DASB. Depressed PD patients displayed a wide-spread increase (8-68%) in [(11)C]DASB specific binding outside of the striatum, which was significant in dorsolateral (37%) and prefrontal (68%) cortices. Elevated [(11)C]DASB binding was positively correlated with depressive symptoms but not with disease severity or duration. Compatible with recent PET/[(11)C]DASB findings in major depression, the present preliminary data suggest that increased [(11)C]DASB binding, possibly reflecting greater serotonin transporter density (up-regulation), might be a pathological feature of depression in Parkinson's disease-and possibly a characteristic of depressive illness in general.

• Authors: Isabelle Boileau, Jerry J Warsh, Mark Guttman, Jean A Saint-Cyr, Tina McCluskey, Pablo Rusjan, Sylvain Houle, Alan A Wilson, Jeffrey H Meyer, Stephen J Kish
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 23 Issue 12 Pg. 1776-80 (Sep 15 2008) ISSN: 1531-8257 [Electronic] United States
• PMID: 18661545 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2007 Movement Disorder Society.

Chemical References

• 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile
• Aniline Compounds
• Serotonin Plasma Membrane Transport Proteins
• Sulfides

Topics

• Aged
• Aniline Compounds
• Case-Control Studies
• Depression (diagnostic imaging, etiology, pathology)
• Female
• Humans
• Male
• Middle Aged
• Parkinson Disease (complications, diagnostic imaging)
• Positron-Emission Tomography (methods)
• Prefrontal Cortex (diagnostic imaging)
• Protein Binding (drug effects)
• Psychiatric Status Rating Scales
• Serotonin Plasma Membrane Transport Proteins (metabolism)
• Statistics, Nonparametric
• Sulfides