Abstract |
A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established.
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Authors | Hee-Yoon Lee, Yongsik Jung, Wonyeob Kim, Jin Hee Kim, Min-Soo Suh, Seung Koo Shin, Hye-Joo Yoon |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 18
Issue 16
Pg. 4670-4
(Aug 15 2008)
ISSN: 1464-3405 [Electronic] England |
PMID | 18656350
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Carbazoles
- Piperazines
- incentrom A
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Topics |
- Antifungal Agents
(pharmacology)
- Carbazoles
(chemical synthesis, pharmacology)
- Cell Proliferation
(drug effects)
- Chemistry, Pharmaceutical
(methods)
- Chromosomal Instability
- Chromosome Segregation
(drug effects)
- Drug Design
- Mitosis
- Models, Chemical
- Molecular Structure
- Piperazines
(chemical synthesis, pharmacology)
- Saccharomyces cerevisiae
(metabolism)
- Structure-Activity Relationship
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