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Structure-activity relationship studies of the chromosome segregation inhibitor, Incentrom A.

Abstract
A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established.
AuthorsHee-Yoon Lee, Yongsik Jung, Wonyeob Kim, Jin Hee Kim, Min-Soo Suh, Seung Koo Shin, Hye-Joo Yoon
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 18 Issue 16 Pg. 4670-4 (Aug 15 2008) ISSN: 1464-3405 [Electronic] England
PMID18656350 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Carbazoles
  • Piperazines
  • incentrom A
Topics
  • Antifungal Agents (pharmacology)
  • Carbazoles (chemical synthesis, pharmacology)
  • Cell Proliferation (drug effects)
  • Chemistry, Pharmaceutical (methods)
  • Chromosomal Instability
  • Chromosome Segregation (drug effects)
  • Drug Design
  • Mitosis
  • Models, Chemical
  • Molecular Structure
  • Piperazines (chemical synthesis, pharmacology)
  • Saccharomyces cerevisiae (metabolism)
  • Structure-Activity Relationship

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