Pachydermoperiostosis with myelofibrosis and anemia: report of a case of anemia of multifactorial causes and its improvement with steroid pulse and iron therapy.

Abstract

A 26-year-old male patient with pachydermoperiostosis is reported. He had severe anemia with myelofibrosis. Treatment with iron, prednisolone, oxymethorone and 1 alpha (OH)D3 were not satisfactory. But steroid pulse therapy with parenteral iron improved his anemia and pancytopenia, but was not sufficient to relieve the bone marrow fibrosis or splenomegaly. The mechanism of anemia which was considered to be multifactorial including gastro-intestinal bleeding associated with peptic ulcer or erosion and bone marrow failure due to myelofibrosis, is discussed.

• Authors: H Tanaka, S Maehama, F Imanaka, A Sakai, K Abe, M Hamada, J Yamashita, A Kimura, N Imamura, K Fujimura
• Journal: Japanese journal of medicine (Jpn J Med) 1991 Jan-Feb Vol. 30 Issue 1 Pg. 73-80 ISSN: 0021-5120 [Print] Japan
• PMID: 1865580 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Hydroxycholecalciferols
• Prednisolone
• Iron
• alfacalcidol
• Methylprednisolone

Topics

• Adult
• Anemia (drug therapy, etiology)
• Gastrointestinal Hemorrhage (complications)
• Humans
• Hydroxycholecalciferols (therapeutic use)
• Iron (therapeutic use)
• Iron Deficiencies
• Male
• Methylprednisolone (therapeutic use)
• Osteoarthropathy, Primary Hypertrophic (complications, genetics)
• Pedigree
• Prednisolone (therapeutic use)
• Primary Myelofibrosis (etiology)