Abstract | PURPOSE: METHODS: Adult patients experiencing symptoms of ARI and meeting the physician's usual diagnostic criteria for oral antibiotic treatment were prescribed an antibiotic and randomized to adjunctive guaifenesin/ pseudoephedrine hydrochloride or matching placebo twice daily for 7 days. Patients completed symptom diaries and treatment assessments twice daily and attended office visits on Days 4 and 8. RESULTS: CONCLUSIONS: As adjunctive therapy for symptom relief for patients taking antibiotics for ARIs, guaifenesin/ pseudoephedrine shortened time to relief and improved bothersome respiratory symptoms better than placebo, with greatest effects seen for nasal congestion and sinus headache.
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Authors | Craig LaForce, Deborah A Gentile, David P Skoner |
Journal | Postgraduate medicine
(Postgrad Med)
Vol. 120
Issue 2
Pg. 53-9
(Jul 2008)
ISSN: 1941-9260 [Electronic] England |
PMID | 18654069
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Delayed-Action Preparations
- Drug Combinations
- Expectorants
- Nasal Decongestants
- Guaifenesin
- Pseudoephedrine
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Topics |
- Administration, Oral
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Delayed-Action Preparations
- Double-Blind Method
- Drug Combinations
- Expectorants
(administration & dosage)
- Female
- Guaifenesin
(administration & dosage)
- Humans
- Male
- Middle Aged
- Nasal Decongestants
(administration & dosage)
- Pseudoephedrine
(administration & dosage)
- Respiratory Tract Infections
(complications, drug therapy)
- Treatment Outcome
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