[Hepatic and renal injury induced by Radix Aristolochiae or Guanxin Suhe Wan for a long-term in rats].

Abstract

OBJECTIVE:

To evaluate the toxicity of Radix Aristolochiae supplied experimental evidence of rational use of drug in clinic.

METHOD:

After treatment with small dose Radix Aristolochiae, Guanxin Suhe Wan (with Radix Aristolochiae) and Guanxin Suhe Wan (without Radix Aristolochiae) in different group for a long- term, respectively, the biochemical indicator of PT, ALT, AST, ALB, ALP, Crea and BUN were detected, and the kidney, liver, stomach and urinary bladder were examined by pathologic assaying.

RESULT:

In Radix Aristolochiae group and Guanxin Suhe Wan (with Radix Aristolochiae) group, all of biochemical indicator were changed significantly, and hepatonecrosis, renal tubular necrosis, gastric carcinoma and bladder carcinoma were discovered.

CONCLUSION:

Radix Aristolochiae and Guanxin Suhe Wan (with Radix Aristolochiae) can damage kidney and liver, and cause gastric carcinoma and bladder carcinoma by intensive toxicity.

• Authors: Hong-Xiang Qiao, Yong-Ye Liu, Li-Mao Wu, Lian-Da Li
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 33 Issue 9 Pg. 1044-8 (May 2008) ISSN: 1001-5302 [Print] China
• PMID: 18652354 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• guanxin suhe wan

Topics

• Animals
• Aristolochia (chemistry, toxicity)
• Drugs, Chinese Herbal (toxicity)
• Kidney (drug effects, metabolism, pathology)
• Liver (drug effects, metabolism, pathology)
• Male
• Rats
• Rats, Sprague-Dawley
• Stomach Neoplasms (chemically induced)
• Urinary Bladder (drug effects, metabolism, pathology)
• Urinary Bladder Neoplasms (chemically induced)